Few workplaces are as complex as a healthcare facility. Such complex situations provide a great deal of potential health and safety hazards. When compared with the total civilian workforce, hospital workers have a greater percentage of workers’ compensation claims for sprains and strains, infectious and parasitic diseases, dermatitis, hepatitis, mental disorders, eye diseases, influenza, and toxic hepatitis.1 The list of potential hazards includes radiation, toxic chemicals, biological hazards, heat, noise, dust, and stress. The risks and exposures for blood and body fluids are important, but not included in this course. Information about the risks and exposures to blood and body fluids are available in a separate course entitled OSHA: Occupational Exposure to Blood and Body Fluids, at CEUFast.com.
All healthcare facilities are required to have detailed information about the chemicals that are at the worksite. This information is in a standard format called a Material Safety Data Sheet (MSDS). The MSDS should be readily available to every worker. Access to the MSDS allows every worker to educate himself about the chemicals at the worksite. Chemicals may exert acute or chronic effects on workers. The effects depend on the:
The effects exerted by a substance may also be influenced by the presence of other chemicals and physical agents or by an individual’s use of tobacco, alcohol, or drugs. The exposure dose is the amount of a substance that enters the body during the period of exposure. The substance continues to be present in the body until it is metabolized or eliminated. Although some chemicals are rapidly metabolized, others area not and may be excreted unchanged or stored in the fatty tissues (solvents), lungs (dust and fibers), bone (lead and radium), or blood (soluble gasses).
Toxic substances can enter the body through several routes, including the intact skin, the respiratory system (inhalation), the mouth (inhalation and ingestion), the eyes, and by accidental needle punctures. Inhalation and skin exposure are the most likely. Some substances can also damage the skin or eyes directly without being absorbed. Not all substances can enter the body through all routes. Inorganic lead, for example, can be inhaled or swallowed, but it does not penetrate the skin. Exposures routes for antineoplastic and other hazardous drugs are inhalation, skin absorption, ingestion, and injection.
The National Institute of Occupational Health and Safety (NIOSH) released new guidelines, in 2016, about the handling of antineoplastic and other hazardous drugs. NIOSH warns that exposure to hazardous drugs may occur to clinical and non-clinical workers in the following settings2:
NIOSH defines the healthcare workers’ responsibilities in relation to antineoplastic and other hazardous drugs as the following2:
Ms. Marvel, a night Nursing Supervisor, was responsible for preparing any IV medications until a new night pharmacist was hired. She was instructed on how to prepare these agents within a ventilated cabinet designed to protect workers and adjacent personnel from exposure and to provide product protection for all drugs that require aseptic handling. Before preparing these medications, she had to dress the part and double glove while protecting her hands and wrists. If there was a chemical spill, she had to immediately use appropriate safety precautions and personal protective equipment unless the spill was large enough to require an environmental service specialist.
She also had to educate the ICU nurses and medical-surgical nurses on safe administration of these medications and their side effects. Mr. Marval worked with nursing educators to prepare written instructions for all units where this information was needed to prevent dangerous workplace injuries. When making hospital rounds, she made sure that the nurses knew where the MSDS information book was located and that it was up-to-date.
One major source of injury to healthcare workers is musculoskeletal disorders (MSDs). In 2010, nursing aides, orderlies, and attendants had the highest rates of MSDs. There were 27,020 cases, which equates to an incidence rate (IR) of 249 per 10,000 workers, more than seven times the average for all industries; this contributed to the all-worker days-away-from-work rate of 34 per 10,000 workers. In 2010, the average incidence rate for musculoskeletal disorder (MSD) cases with days away from work increased 4 percent, while the MSD incidence rate for nursing aides, orderlies, and attendants increased 10 percent.4
These injuries are due in large part to overexertion related to repeated manual patient handling activities, often involving heavy manual lifting associated with transferring, and repositioning patients and working in extremely awkward postures.4
Nearly half of all compensation claims for hospital workers involved back injuries. The most common causes of all work-related back pain are as follow 1, 4:
Factors that contribute to these causes of back pain are understaffing, the lack of regular training programs in proper procedures for lifting and other work motions, and inadequate general safety precautions. Written guides and programs for preventing back injury are available for all workers. The primary approach to preventing back injury involves reducing manual lifting and other load-handling tasks that are biomechanically stressful. The secondary approach is to train workers how to perform stressful tasks while minimizing the biomechanical forces on their backs, and how to maintain flexibility and strengthen the back and abdominal muscles. To prevent back injury, workers should1:
Patient transfers are particularly hazardous for hospital workers. The following special points should be emphasized to prevent back injuries during transfers.
Accident hazards such as wet floors, stairway obstructions, and faulty ladders should be reduced. Wet-floor hazards can be reduced by proper housekeeping procedures such as marking wet areas, cleaning up spills immediately, cleaning only one side of a passageway at a time, keeping halls and stairways clear, and providing good lighting for all halls and stairwells. Workers should be instructed to use the handrail on stairs, to avoid undue speed, and to maintain an unobstructed view of the stairs ahead of them, even if that means requesting help to manage a bulky load.
The consequences of work-related musculoskeletal injuries among nurses are substantial. Along with higher employer costs due to medical expenses, disability compensation, and litigation, nurse injuries also are costly regarding chronic pain and functional disability, absenteeism, and turnover. Approximately 20% of nurses who leave direct patient care positions do so because of risks associated with the work. Many healthcare workers, who experience pain and fatigue, may be less attentive, less productive, more susceptible to further injury, and may be more likely to affect the health and safety of others.4 Direct and indirect costs associated with only back injuries in the healthcare industry are estimated to be $20 billion annually.4
David, a float CNA, was educated on how to use the newest lift equipment and techniques to use when transferring patients from their wheelchairs to their beds and visa-verse. He constantly encouraged the staff he worked with to ask for assistance when handling residents who were unable to help themselves or required more than one person to assist them in moving. Before using any lift-equipment, he made sure all lines and hooks were secured, and the equipment functioned safely and properly. Especially in the secure units where many of the patients have dementia or Alzheimer’s disease, he instructed the staff always to work as a cohesive team. The individual at the head of the patient was to be in charge, and they would discuss ahead of time the process they would use. Patients were told what was going to be done and why before staff transferred them. Questions were answered at patient’s level of understanding. David was always in demand!
Hospital fires and disasters are especially dangerous because workers must protect themselves and evacuate large numbers of patients. Almost one-third of hospital fires originated in patient rooms or worker quarters, with matches and smoking as the most frequent cause. Other causes are malfunctioning or misused electrical equipment such as hot plates, coffee pots, and toaster ovens.1
Deaths during hospital fires were overwhelmingly due to inhaling the toxic products of combustion rather than to direct exposure to the fire. Another obvious fire hazard is the use of oxygen in patient areas. Fires can occur in an oxygen-enriched atmosphere because of patient smoking, electrical malfunctions, and the use of flammable liquids. Procedures should be developed and strictly enforced to prevent fire hazards in patient areas where oxygen is used. When you enter a new work area, look around and find fire alarms, fire extinguishers, exit signs and oxygen cut off valves.
One way to remember fire safety is the acronym, RACE.
When rescuing anyone in immediate danger, remember to stay low. Smoke rises to the ceiling and forms a heavy, dense cloud that slowly descends. This cloud is deadly because it contains toxic gasses. Do not ever hesitate to sound the alarm with any suspicion of fire, but never yell fire. That will only create panic. Call out the facilities code for fire. Call the switchboard to report the fire and pull the fire alarm. When you call the switchboard, be sure to stay on the phone long enough to assure they got the correct information.
Healthcare units are separated by heavy fire doors that close automatically when the alarm is sounded, to keep the fire from spreading. To confine a fire, close doors, windows and all vertical openings like the laundry chute. Stuff wet towels under doors to keep smoke out. Shut off oxygen supplies if directed to do so. Usually, someone in supervision is designated to decide when to turn off oxygen supplies.
If a fire is small and confined, you may be able to extinguish it. If a patient's clothes are on fire, wrap the patient tightly in a large blanket to extinguish the flames. If a piece of equipment catches fire, pull the plug or cut the electricity as soon as possible.
If a fire cannot be extinguished and smoke, fumes or flames threaten patient safety, you may have to evacuate. Evacuate ambulatory patients first. Stay calm and give clear directions. Evacuate horizontally as long as you can. Then evaluate vertically down to a lower level. Never use an elevator to escape during a fire. A sudden loss of power could leave you trapped in the elevator.
Fire extinguishers come in different classes for use on fires of different sources. The extinguisher has small pictures on the label that help you identify the type of fire source material in which they should be used. Class A puts out fires involving ordinary combustibles. Class B extinguishers smother fires involving flammable liquids or gasses. Class C extinguishers put out fires in or near electrical equipment. Type ABC extinguishers can be used to fight all three types of fires. To use an extinguisher, pull the pin; Aim the nozzle at the base of the fire; and squeeze the trigger, while you make sweeping strokes.
Max, an educator and environmental engineer, was responsible for ensuring that staff from all departments knew what to do in case of a fire. He worked on all shifts and reviewed the emergency plan and made sure the Charge Nurse knew he/she was responsible for turning off the oxygen in the units and assigning roles to her healthcare team. All employees had to know what the number/code was to announce a fire and its location. Exits to be taken were reinforced, and the healthcare team had to make sure they worked together as a cohesive team without causing people to panic. Staff had to demonstrate to Max that they knew where the fire alarms and extinguishers were located and had to explain how to use them. Staff had to practice using the emergency sleds located on the beds to transport disabled patients. Special mandatory hands-on workshops were held during the day. Max did this on a quarterly basis and provided documentation to the key administrators that this was completed.
Disaster plans should be prepared for natural events (e.g. tornadoes, earthquakes and hurricanes), gas leaks, and bomb threats. The plans should be written and readily available. Supervisory workers will initiate the disaster plan and designate task to workers. Workers are responsible for knowing the alarm code for a disaster and the exit routes.
A major hazard in all hospitals is the widespread use and storage of flammable and combustible liquids. Many liquids have vapors that are flammable or combustible and can be ignited by a spark from a motor, friction, or static electricity. Handling and storage directions must be followed.
Compressed gasses are under pressure and are flammable, so they must be handled with extreme care. An exploding cylinder can have the same destructive effect as a bomb. The proper handling of compressed gas cylinders requires training. Storage areas for compressed gas cylinders should be well ventilated, fireproof, and dry. Cylinders should not be stored near steam pipes, hot water pipes, boilers, highly flammable solvents, combustible wastes, unprotected electrical connections, open flames, or other potential sources of heat or ignition. Cylinders should be properly labeled. The valve protection cap should not be removed until the cylinder is secured and ready for use.
Compressed gasses used in hospitals include acetylene, ammonia, anesthetic gasses, argon, chlorine, ethylene oxide, helium, hydrogen, methyl chloride, nitrogen, and sulfur dioxide. Acetylene, ethylene oxide, methyl chloride, and hydrogen are flammable, as are the anesthetic agents, cyclopropane, diethyl ether, ethyl chloride, and ethylene. Although oxygen and nitrous oxide are labeled as nonflammable, they are oxidizing gasses that will aid combustion.
Violations of standards governing the use of electrical equipment are the most frequently cited causes of electrical fires. Thorough electrical maintenance records should be kept, and considerable effort should be devoted to electrical safety, particularly in areas where patient care is involved. Equipment and appliances that are frequently ungrounded or incorrectly grounded include1:
Workplace violence is a serious concern for the approximately 15 million health care workers in the United States. OSHA is the federal agency responsible for protecting the safety and health of the nation's workers, although states may assume responsibility under an OSHA-approved plan. OSHA does not require employers to implement workplace violence prevention programs, but it provides voluntary guidelines and may cite employers for failing to provide a workplace free from recognized serious hazards.5
The circumstances of hospital violence differ from the circumstances of workplace violence in general. In other workplaces such as convenience stores and taxicabs, violence most often relates to robbery. Violence in hospitals usually results from patients and occasionally from their family members who feel frustrated, vulnerable, and out of control. Common risk factors for hospital violence include the following6:
Violence may occur anywhere in the hospital, but it is most frequent in psychiatric wards, emergency rooms, waiting rooms, and geriatric units.4 Studies indicate that violence often takes place during times of high activity and interaction with patients. Assaults may occur when service is denied, when a patient is involuntarily admitted, or when a healthcare worker attempts to set limits on eating, drinking, or tobacco or alcohol use.4 Patients with a condition that causes confusion and impaired judgment are more likely to become violent than a patient with normal mentation. Confusion and impaired judgment may be caused by neurologic conditions, seizures, hypoglycemia, or dementia.7
Watch for signals that may be associated with impending violence4:
Note how your co-workers behave. If a colleague’s demeanor or behavior has changed for the worse, notify your manager. For example, slamming equipment around is red-flag behavior. Learn from their history. If a patient has a history of violent behavior (such as acting combative in the ambulance or waiting room), prepare yourself for potentially violent behavior and warn others who are caring for him. Let security know if you feel threatened or if you find or suspect that he's carrying a weapon. Notify your nursing supervisor, manager, and hospital security or police if you suspect a patient is going to be violent. Keep your patient informed. Help relieve his tension and anxiety by keeping him informed about when he'll be examined or treated and what's going on.7
Be alert6:
Always keep an open path for exiting. Do not let the potentially violent person stand between you and the door. When you're with an upset patient or co-worker, avoid areas of the room that do not have an accessible exit. If you're going to an isolated part of your facility, let others know where you're going and when you expect to return. Consider asking for an escort. Observe your surroundings and note anyone who is not wearing staff ID and is lingering where he should not. Ask politely if you can help him and notify security if you aren't satisfied with his answer. If you'd rather not approach someone, call security and provide a full description. Evaluate the way you wear equipment to be sure it cannot be used as a weapon against you. For example, consider that a stethoscope or ID badge without a breakaway necklace can be used to choke you. Carry your stethoscope in a pocket and use an ID badge necklace that has a breakaway feature. If you wear a necktie, opt for a clip-on style. If your hair is long, wear it in a way that's not easy to pull, and do not wear dangling jewelry.7
In the presence of a potentially violent person7:
Do
Do not
Take these steps if you cannot defuse the situation quickly6:
In the presence of a weapon, maintain behavior that helps diffuse anger6:
Up to 4 million women employed in hospitals may be exposed to reproductive hazards. However, there is no clear evidence that exposure conditions in hospitals have resulted in an excess rate of birth defects among the offspring of hospital workers.8 Studies do support more general associations between employment in hospitals or laboratories and an increased risk of adverse reproductive effects, primarily spontaneous abortion. Workers with immunity through vaccinations or earlier exposures are not generally at risk for diseases such as hepatitis B, human parvovirus B19, German measles, or chicken pox. But pregnant workers without prior immunity should avoid contact with infected children or adults. Workers should also use good hygienic practices such as frequent handwashing to prevent the spread of infectious diseases and universal precautions.8 In addition to many of these drugs being cytotoxic, the majority are hazardous to males or females who are actively trying to conceive, women who are pregnant or may become pregnant, and women who are breastfeeding, because they may be present in breast milk. These drugs represent an occupational hazard to healthcare workers and should always be handled with the use of recommended engineering controls and personal protective equipment (PPE), regardless of their formulation (IV [intravenous], SC [subcutaneous], topical, tablet, or capsule). Unopened, intact tablets and capsules may not pose the same degree of occupational exposure risk as injectable drugs, which usually require extensive preparation. Cutting, crushing, or otherwise manipulating tablets and capsules will increase the risk of exposure to workers.8
The following tables outline the hazards and effects.8(p1)
Agent | Observed effects | Potentially exposed workers |
---|---|---|
Cancer treatment drugs (e.g., methotrexate) | Infertility, miscarriage, birth defects, low birth weight | Healthcare workers, pharmacists |
Certain ethylene glycol ethers such as 2-ethoxyethanol (2EE) and 2-methoxyethanol (2ME) | Miscarriages | Electronic and semiconductor workers |
Carbon disulfide (CS2) | Menstrual cycle changes | Viscose rayon workers |
Lead | Infertility, miscarriage, low birth weight, developmental disorders | Battery makers, solderers, welders, radiator repairers, bridge repainters, firing range workers, home remodelers |
Ionizing radiation (e.g., X-rays and gamma rays) | Infertility, miscarriage, birth defects, low birth weight, developmental disorders, childhood cancers | Healthcare workers, dental personnel, atomic workers |
Strenuous physical labor (e.g., prolonged standing, heavy lifting) | Miscarriage late in pregnancy, premature delivery | Many types of workers |
Agent | Observed effects | Potentially exposed workers | Preventive measures |
---|---|---|---|
Cytomegalo- virus (CMV) | Birth defects, low birth weight, developmental disorders | Healthcare workers, workers in contact with infants and children | Good hygienic practices such as handwashing |
Hepatitis B virus | Low birth weight | Healthcare workers | Vaccination |
Human immuno-deficiency virus (HIV) | Low birth weight, childhood cancer | Healthcare workers | Practice universal precautions |
Human parvovirus B19 | Miscarriage | Healthcare workers, workers in contact with infants and children | Good hygienic practices such as handwashing |
Rubella (German measles) | Birth defects, low birth weight | Healthcare workers, workers in contact with infants and children | Vaccination before pregnancy if no prior immunity |
Toxoplas-mosis | Miscarriage, birth defects, developmental disorders | Animal care workers, veterinarians | Good hygiene practices such as handwashing |
Varicella- zoster virus (chicken pox) | Birth defects, low birth weight | Healthcare workers, workers in contact with infants and children | Vaccination before pregnancy if no prior immunity |
Workers with immunity through vaccinations or earlier exposures are not generally at risk for diseases such as hepatitis B, human parvovirus B19, German measles, or chicken pox. But pregnant workers without prior immunity should avoid contact with infected children or adults. Workers should also use good hygienic practices such as frequent handwashing to prevent the spread of infectious diseases and universal precautions.8
‡BCG, although classified as a vaccine, is used in the treatment of certain cancers. BCG should be prepared with aseptic techniques. Parenteral drugs should not be prepared in areas where BCG has been prepared to prevent cross-contamination. A separate area for the preparation of BCG suspension is recommended. All equipment, supplies, and receptacles in contact with BCG should be handled and disposed of as biohazardous. If preparation cannot be performed in a containment device, then respiratory protection, gloves, and a gown should be worn to avoid inhalation or contact with BCG organisms.
NIOSH performs a hazard identification for each of the drugs listed based on its criteria as described above. The actual risk to healthcare workers depends on the toxicity of the drugs, how the drugs can enter the body (e.g., dermal, inhalation, or ingestion), and how the drugs are handled. Also of concern is how the drugs are manipulated, how often they are handled, and the exposure controls in place, such as the type of engineering controls and personal protective equipment (PPE). For example:
Group 1: Antineoplastic drugs, including those with the manufacturer’s safe-handling guidance (MSHG). Abbreviations: AHFS = American Hospital Formulary Service; MRHD = maximum recommended human dose.
NIOSH’s updated list of the newest 2016 drugs are noted below:
The 2016 drugs listed below in Table 1 meet one or more of the NIOSH criteria for a hazardous drug. In addition to many of these drugs being cytotoxic, the majority are hazardous to males or females who are actively trying to conceive, women who are pregnant or may become pregnant, and women who are breastfeeding, because they may be present in breast milk. These drugs represent an occupational hazard to healthcare workers and should always be handled with the use of recommended engineering controls and personal protective equipment (PPE), regardless of their formulation (IV [intravenous], SC [subcutaneous], topical, tablet, or capsule). Unopened, intact tablets and capsules may not pose the same degree of occupational exposure risk as injectable drugs, which usually require extensive preparation. Cutting, crushing, or otherwise manipulating tablets and capsules will increase the risk of exposure to workers. The manufacturer’s safe-handling guidance (MSHG) is typically in Section 16 of the DPI. See Table 5 for safe-handling recommendations.2
Drug | AHFS classification | MSHG | Supplemental information | Links |
---|---|---|---|---|
afatinib* | 10:00 antineoplastic agents | Special warnings on contraception for females while taking and 2 weeks post-treatment; FDA Pregnancy Category D | DailyMed; DrugBank | |
axitinib | 10:00 antineoplastic agents | Teratogenic, embryotoxic and fetotoxic in mice at exposures lower than human exposures; FDA Pregnancy category D | DailyMed; DrugBank | |
belinostat | 10:00 antineoplastic agents | yes | May cause teratogenicity and/or embryo-fetal lethality because it is a genotoxic drug and targets actively dividing cells; FDA Pregnancy Category D | DailyMed; DrugBank |
bosutinib | 10:00 antineoplastic agents | FDA Pregnancy Category D | DailyMed; DrugBank | |
cabozantinib | 10:00 antineoplastic agents | agents Embryolethal in rats at exposures below the recommended human dose; FDA Pregnancy category D | DailyMed; DrugBank | |
carfilzomib | 10:00 antineoplastic agents | agents Special warnings on contraception while taking and 2 weeks post- treatment; FDA Pregnancy category D | DailyMed; DrugBank | |
dabrafenib | 10:00 antineoplastic agents | Special warnings on contraception for females while taking and 2 weeks post-treatment; FDA Pregnancy Category D | DailyMed; DrugBank | |
enzalutamide | 10:00 antineoplastic agents | Embryo-fetal toxicity in mice at exposures that were lower than in patients receiving the recommended dose; FDA Pregnancy Category X | DailyMed; DrugBank | |
histrelin | 10:00 antineoplastic agents | Can cause fetal harm when administered to a pregnant patient, with the possibility of spontaneous abortion; FDA Pregnancy Category X | DailyMed; DrugBank | |
ixazomib | 10:00 antineoplastic agents | yes | Male and female patients of childbearing potential must use effective contraceptive measures during and for 3 months following treatment | DailyMed; DrugBank |
panobinostat | 10:00 antineoplastic agents | yes | Special warnings on contraception for females while taking and 1 month post-treatment | DailyMed; DrugBank |
pertuzumab | 10:00 antineoplastic agents | Black Box warning on embryo-fetal death and birth defects; FDA Pregnancy Category D | DailyMed; DrugBank | |
pomalidomide | 10:00 antineoplastic agents | yes | Females of reproductive potential must use two forms of contraception or continuously abstain from heterosexual sex during and for 4 weeks after stopping treatment; FDA Pregnancy Category X |
DrugBank |
ponatinib | 10:00 antineoplastic agents | FDA Pregnancy Category D | DailyMed; DrugBank | |
regorafenib | 10:00 antineoplastic agents | Black Box warning on severe and sometimes fatal hepatotoxicity; total loss of pregnancy at doses lower than recommended human dose; FDA Pregnancy Category D | DailyMed; DrugBank | |
trametinib | 10:00 antineoplastic agents | Embryotoxic and abortifacient at doses less than recommended human dose; FDA Pregnancy Category D | DailyMed; DrugBank | |
trifluridine/tipiracil (combination only) | 10:00 antineoplastic agents | yes | Embryo-fetal lethality and embryo-fetal toxicity at doses lower than or similar to exposures at the recommended human dose | DailyMed; DrugBank |
vismodegib | 10:00 antineoplastic agents | Black Box warning on embryo-fetal death or severe birth defects; recommend effective contraception for females during therapy and for 7 months after treatment; present in semen; no sperm donation during and 3 months posttreatment; FDA Pregnancy Category D | DailyMed; DrugBank | |
ziv-aflibercept | 10:00 antineoplastic agents | Embryotoxic and teratogenic in rabbits at exposure levels lower than human exposures at the recommended dose, with increased incidences of external, visceral, and skeletal fetal malformations; FDA Pregnancy Category C | DailyMed; DrugBank |
Drug | AHFS classification | MSHG | Supplemental information | Links |
---|---|---|---|---|
methimazole‡ | 68:36:08 antithyroid agents | Appears in human breast milk; FDA Pregnancy Category D | DailyMed; DrugBank | |
mipomersen | 24:06:92 antilipemic agents, miscellaneous | Black Box warning on hepatotoxicity; FDA Pregnancy Category B | DailyMed; DrugBank | |
ospemifene | 68:16:12 estrogen agonists-antagonists | Black Box warning on increased risk of endometrial cancer in certain populations; risk of adverse outcomes during pregnancy and labor; FDA Pregnancy Category X | DailyMed; DrugBank | |
paliperidone | 28:16:08:04 atypical antipsychotics | Metabolite of risperidone; excreted in human breast milk; FDA Pregnancy Category | DailyMed; DrugBank | |
teriflunomide | 92:20 immunomodulatory agents | Black Box warning on severe hepatotoxicity and teratogenicity, including major birth defects; FDA Pregnancy Category X | DailyMed; DrugBank | |
tofacitinib | 92:36 disease modifying antirheumatic drugs | Black Box warning for lymphoma and other malignancies; FDA Pregnancy Category C |
DrugBank |
Drug | AHFS classification | MSHG | Supplemental information | Links |
---|---|---|---|---|
clomiphene* | 68:16:12 estrogen agonist-antagonists | FDA Pregnancy Category X | DailyMed; DrugBank | |
eslicarbazepine | 28:12:92 anticonvulsants, miscellaneous | Fetal malformations, fetal growth retardation, embryolethality, and reduced body weights observed in animal studies; excreted in human breast milk; FDA Pregnancy Category C | DailyMed; DrugBank | |
lomitapide | 24:06:92 antilipemic agents, miscellaneous | FDA Pregnancy Category X | DailyMed; DrugBank | |
macitentan | 48:48 vasodilating agents | Black Box warning for embryofetal toxicity; special warnings on contraception for females while taking and 1 month post-treatment; FDA Pregnancy Category X | DailyMed: DrugBank | |
pamidronate | 92:24 bone resorption inhibitors | Embryo-fetal toxicities at doses below the recommended human dose; FDA Pregnancy Category D | DailyMed; DrugBank | |
pasireotide | 68:29:04 somostatin agonists | Increased implantation loss and decreased viable fetuses, corpora lutea, and implantation sites at doses less than the human recommended dose; FDA Pregnancy Category C | DailyMed; DrugBank | |
peginesatide | 20:16 hematopoietic agents | Adverse embryo-fetal effects, including reduced fetal weight, increased resorption, embryofetal lethality, and cleft palate, observed in doses below the recommended human dose; FDA Pregnancy Category C | DailyMed; DrugBank | |
riociguat | 48:48 vasodilating agents | Exclude pregnancy before the start of treatment, monthly during treatment, and 1 month after stopping treatment; FDA Pregnancy Category X | DailyMed; DrugBank | |
temazepam | 28:24:08 benzodiazepines | Increased risk of congenital malformations associated with treatment during the first trimester of pregnancy; FDA Pregnancy Category X | DailyMed; DrugBank |
Table 5: Would list drugs that were deleted from the 2014 NIOSH hazardous drug list for the 2016 update; however, there are no deletions to report |
Formulation | Activity | Double chemo-therapy gloves | Protective gown | Eye/face protection | Respiratory protection | Ventilated engineering control |
---|---|---|---|---|---|---|
All types of hazardous drugs | Receiving, unpacking, and placing in storage | No (single glove can be used, unless spills occur) | Yes, when spills and leaks occur | No | Yes, when spills and leaks occur | No |
Intact tablet or capsule | Administration from unit-dose package | No (single glove can be used) | No | No | No | N/A |
Tablets or Capsules | Cutting, crushing, or manipulating tablets or capsules; handling uncoated tablets | Yes | Yes | No | Yes, if not done in a control device | Yes |
Administration | No (single glove can be used) | No | Yes, if vomit or potential to spit up | No | N/A | |
Oral liquid drug or feeding tube | Receiving, unpacking, and placing in storage | No (single glove can be used, unless spills occur) | Yes, when spills and leaks occur | No | Yes, when spills and leaks occur | No |
Topical drug | Compounding | Yes | Yes | Yes, if not done in a control device | Yes, if not done in a control device | Yes†, BSC or CACI (Note: carmustine and mustargen are volatile) |
Administration | Yes | Yes | Yes, if liquid that could splash‡ | Yes, if inhalation potential | N/A | |
Subcutaneous/ intra-muscular injection from a vial | Preparation (withdrawing from vial) | Yes | Yes | Yes, if not done in a control device | Yes, if not done in a control device | Yes, BSC or CACI |
Administration | Yes | Yes | Yes, if liquid that could splash‡ | No | N/A | |
Withdrawing and/or mixing intravenous or intramuscular solution from a vial or ampoule | Compounding | Yes | Yes | No | No | BSC or CACI; use of CSTD re-commended |
Administration of prepared solution | Yes | Yes | Yes; if liquid that could splash | No | N/A; CSTD required per USP 800 if the dosage form allows | |
Solution for irrigation | Compounding | Yes | Yes | Yes, if not done in a control device | Yes, if not done in a control device | Yes, BSC or CACI; use of CSTD re-commended |
Administration (bladder, HIPEC, limb perfusion, etc.) | Yes | Yes | Yes | Yes | N/A | |
Powder/solution for inhalation/ aerosol treatment | Compounding | Yes | Yes | Yes, if not done in a control device | Yes, if not done in a control device | Yes, BSC or CACI; use of CSTD recommended |
Aerosol administration | Yes | Yes | Yes | Yes | Yes, when applicable | |
Administration | Yes | Yes | Yes, if liquid that could splash‡ | Yes, if inhalation potential | N/A | |
Drugs and metabolites in body fluids | Disposal and cleaning | Yes | Yes | Yes, if liquid that could splash | Yes, if inhalation potential | N/A |
Drug-contaminated waste | Disposal and cleaning | Yes | Yes | Yes, if liquid that could splash | Yes, if inhalation potential | N/A |
Spills | Cleaning | Yes | Yes | Yes | Yes | N/A |
Skin injuries and diseases account for a large proportion of all occupational injuries and diseases. Skin injuries in the hospital environment include cuts, lacerations, punctures, abrasions, and burns. Skin diseases and conditions of hospital workers include dermatitis, allergic sensitization, infections such as herpes, and skin cancer. Chemicals can directly irritate the skin or cause an allergic sensitization. Physical agents can also damage the skin, and skin that has been chemically or physically damaged is vulnerable to infection.
The most common, and often the most easily preventable of all job-related health problems, are skin reactions (dermatitis.) The skin is the natural defense system of the body: it has a rough, waxy coating, a layer of protein, keratin, and an outer layer of dead cells to help prevent chemicals from penetrating the tissues and being absorbed into the blood.
Many chemicals cause irritation on contact with the skin, irritant contact dermatitis, by dissolving the protective fats or keratin protein layer, dehydrating the skin, or killing skin cells. Symptoms of this kind of irritation are red, itchy, peeling, dry, or cracking skin. Some chemicals are not irritants under normal conditions, but they will irritate skin that has already been damaged by sunburn, scratching, prolonged soaking, or other means. Tars, oils, and solvents can plug the skin pores and hair follicles, causing blackheads, pimples, and folliculitis.
Some persons become sensitized to chemicals days, months, or even years after their first exposure. This allergic reaction does not occur in every worker who contacts the chemical. Symptoms are red, itchy, and blistering skin, like a poison oak or ivy reaction, and may be much more severe than the direct irritation described in the previous subsection.
The association between basal and squamous cell carcinomas and ultraviolet radiation has been well established. The association between skin cancer and exposure to other agents is less well documented, but ionizing radiation and antineoplastic drugs have been implicated. Other evidence indicates that malignant transformation of cells damaged by chronic allergic contact dermatitis may occur.3
The skin can be damaged by a variety of microorganisms, including bacteria, fungi, viruses, and parasites. Herpes simplex is the most common dermatologic infection among dentists, physicians, and nurses.
Relatively simple precautions can considerably reduce skin hazards. Effective measures include work practices and engineering controls that limit solvent exposure, the use of personal protective equipment, substitution of less irritating chemicals, use of non-powdered gloves, and the institution of a good hygiene program.
Job stress refers to the harmful physical and emotional responses that occur when the requirements of the job do not match the capabilities, resources, or needs of the worker. Job stress can lead to poor health and even injury.2 Hospital work often requires coping with some of the most stressful situations found in any workplace. Hospital workers must deal with life-threatening injuries and illnesses complicated by complex hierarchies of authority and skills, dependent and demanding patients, and patient deaths; all of these contribute to stress. Other important stress factors include job specialization, discrimination, concerns about money, lack of autonomy, work schedules, ergonomic factors, and technological changes. The increasing size and bureaucracy of many hospitals may depersonalize the environment and leave many workers feeling isolated, fatigued, angry, powerless and frustrated. These feelings may be expressed as apathy, loss of self-confidence, withdrawal, or absenteeism. Failure to recognize and treat the sources of stress results in workers who suffer burnout. Factors commonly mentioned as causes of stress by all categories of hospital workers are3:
Stress has been associated with loss of appetite, ulcers, mental disorder, migraines, difficulty in sleeping emotional instability, disruption of social and family life, and the increased use of cigarettes, alcohol, and drugs. Stress can also affect worker attitudes and behavior. Some frequently reported consequences of stress among hospital workers are difficulties in communicating with very ill patients, maintaining pleasant relations with coworkers, and judging the seriousness of a potential emergency.
Many healthcare workers are constantly having to deal with exposures to neoplastic and hazardous drugs. Every year new drugs are developed and each has certain side effects. Fortunately, organizations such as NIOSH, CDC, and DHHS are constantly updating important information telling us how to be safe along with side effects of new chemical agents. Healthcare workers in all departments need to know where their MSDS book is located and have easy access to it. Educators must constantly up-date their safety manuals, educate works on all shifts and in all departments.
In todays’ volatile world healthcare workers and others need to stay informed of how to handle fires, and to be prepared for disasters both man-made and natural. Knowing how to use equipment that can prevent injuries along with practicing using this equipment is imperative.
Workplace violence is everybody’s concern. The key to success is to learn to listen effectively, know when to speak and what to say, respect everybody’s personal distance, and show genuine concern for all those you are in contact with. People need to feel valued and appreciated and know what the consequences are for their actions.
Administrators have the responsibility of making sure healthcare workers are protected from injuries while at work and enforce the consequences when a worker is physically or mentally abused by a patient, relative, or co-worker. Healthcare facilities should be safe havens for all!
CEUFast, Inc. is committed to furthering diversity, equity, and inclusion (DEI). While reflecting on this course content, CEUFast, Inc. would like you to consider your individual perspective and question your own biases. Remember, implicit bias is a form of bias that impacts our practice as healthcare professionals. Implicit bias occurs when we have automatic prejudices, judgments, and/or a general attitude towards a person or a group of people based on associated stereotypes we have formed over time. These automatic thoughts occur without our conscious knowledge and without our intentional desire to discriminate. The concern with implicit bias is that this can impact our actions and decisions with our workplace leadership, colleagues, and even our patients. While it is our universal goal to treat everyone equally, our implicit biases can influence our interactions, assessments, communication, prioritization, and decision-making concerning patients, which can ultimately adversely impact health outcomes. It is important to keep this in mind in order to intentionally work to self-identify our own risk areas where our implicit biases might influence our behaviors. Together, we can cease perpetuating stereotypes and remind each other to remain mindful to help avoid reacting according to biases that are contrary to our conscious beliefs and values.
CDC/NIOSH. NIOSH list of antineoplastic and other hazardous drugs in healthcare settings. Published 2016. (Visit Source). Accessed October 16, 2016
CDC/NIOSH. Staying safe at work. Published 2016. Accessed October 14, 2016
NIOSH Research Rounds. Medical research links stress, including work. Published April, 2016. Accessed October 13, 2016.
CDC. Environmental Health; Workplace Safety. Published 2016. Accessed October 16, 2016.
OSHA. Controlling occupational exposure to hazardous drugs. Published 2016. (Visit Source). Accessed October 10, 2016.