≥ 92% of participants will know how to care for a newborn with neonatal abstinence syndrome NAS.
CEUFast, Inc. is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation. ANCC Provider number #P0274.
≥ 92% of participants will know how to care for a newborn with neonatal abstinence syndrome NAS.
After completing this continuing education course, the learner will be able to:
Neonatal abstinence syndrome (NAS) is experienced by newborns exposed to opioids or other substances, such as benzodiazepines and selective serotonin reuptake inhibitors. An infant exposed to such substances in utero is often at risk of developing withdrawal after birth.
NAS is defined by signs of postnatal drug withdrawal and can occur from exposure to either licit (oxycodone, fentanyl) or illicit substances (heroin) in utero. It is also associated with antenatal exposure to medication used to treat opioid use disorder, such as methadone or buprenorphine. NAS causes major physiological changes in the infant, including respiratory distress, autonomic nervous system dysfunctions, nervous system irritability, and gastrointestinal disturbances.
The United States is experiencing an opioid use crisis, leading to an increased incidence of NAS. The number of infants covered by Medicaid diagnosed with NAS has increased fivefold from 2004 to 2017. In 2004, four per 1000 births resulted in NAS, compared to seven out of 1000 births in 2017 (Hirai et al., 2021). Newborns with NAS stay nine days longer compared to non-NAS newborns, with an average of $14,600 in additional costs (Bhatt et al., 2021). In 2014, $563 million was spent on costs for the treatment of NAS; 82% of this was covered by state Medicaid programs, reflecting the greater tendency of mothers using opioids during pregnancy to be from lower-income communities (Honein et al., 2019).
The pathophysiology of NAS and the various factors that affect the severity is not completely understood today; however, it is directly related to the agonist effects of opioids. These agonist effects of opioids lead to supraspinal analgesia, sedation, euphoria, respiratory depression, and decreased gastrointestinal motility. Opioids at the cellular level inhibit the release of noradrenaline at synaptic terminals. Chronic exposure to opioids causes tolerance as noradrenaline release from the synapse rate increases towards normal. When the discontinuation of opioids occurs at birth, there is a supranormal release of noradrenaline, which then causes autonomic and behavioral symptoms of withdrawal. The mu receptors are more concentrated in the gastrointestinal tissue and the central nervous system; therefore, withdrawal likely includes the central nervous system, overactive autonomic system, and gastrointestinal disturbances (Hirai et al., 2021).
The onset of NAS symptoms and clinical signs of withdrawal vary depending on the history of the intrauterine exposure and the half-life of the substance used. For neonates exposed to maternal heroin and prescription opioids, withdrawal symptoms commonly present in the first 24 hours of life. Clinical signs and symptoms of withdrawal from methadone or buprenorphine generally start between 48 to 72 hours after birth because those substances are long-acting. However, for all opioids, withdrawal may be delayed for up to 5-7 days after birth.
The classic signs of NAS are related to the dysfunction of state of control and attention, motor and tone control, sensory integration, and autonomic functioning.
Healthcare providers caring for infants at risk for NAS based on maternal history or those newborns with suspected NAS are assessed and scored on a specific NAS scale to monitor the presence and severity of their withdrawal and help manage their care. Several screening tools have been developed over the past several decades; however, the Finnegan Neonatal Abstinence Scoring System is the most widely used. Loretta Finnegan developed this tool in 1975 to provide a standardized method for assessing full-term neonates exposed to narcotics. The tool assesses 21 of the most commonly found clinical symptoms and signs of newborn drug withdrawal, and the total score can range from 0-62. The newer function-based approach and assessment of the Eat, Sleep, Console care is gaining use throughout the United States. In 2014, Grossman and colleagues developed the Eat, Sleep, Console approach for the assessment of infants experiencing opioid withdrawal; this approach focuses on the newborn's ability to eat, sleep, and be consoled using nonpharmacologic interventions and empowerment of families and caregiver teams of the newborns (Young et al., 2023).
It should be noted that most of the assessment tools to assess NAS are based on a full-term infant and are not appropriate for use in preterm newborns. Preterm infants less than 35 weeks gestation have lower rates of NAS when compared to full-term newborns. NAS symptoms are noted to be less severe as gestational age decreases. This syndrome is related to the developmental immaturity of the central nervous system and decreased mu receptor development, and a lower amount of fat deposition of substances. Premature infants also have a limited ability to express signs of motor dysfunction and experience reduced total substance exposure during their shortened intrauterine period.
Identification of NAS in neonates is through the reported maternal history of drug use, physical examination, and laboratory tests. The clinical diagnosis of perinatal drug exposure is based on the reported or suspected history of maternal opioid use, positive maternal drug screening, positive newborn drug screen results, or neonates presenting with findings consistent with NAS. Identifying newborns at risk for NAS begins during prenatal care of the mother. Suppose the healthcare team is aware of the maternal use of opioid substances before the newborn's birth. In that case, the team will be able to provide accurate clinical assessments and early interventions and mitigate signs of NAS. However, women are often less likely to self-report illegal drug use with their healthcare providers because of social and legal consequences. Screening for maternal substance use through toxicology requires consent, and currently, there is no consensus on universal screening. In the United States, screening newborns' biological specimens for substance exposure may not require maternal consent based on state laws. Neonatal testing is most commonly performed on urine, although this screening has a low sensitivity.
NAS may also have similar features to other conditions affecting newborns; therefore, clinical signs should not be purely attributed to drug withdrawal without assessment and diagnostic tests to differentiate from other causes.
The care of the newborn at risk for or diagnosed with NAS must be delivered by a nonjudgmental multidisciplinary team trained in the management of maternal substance use disorder and NAS. Social services and healthcare providers must work together to care for the newborn-mother dyad during their hospital stay and outpatient care.
Nursing care for this vulnerable population includes both nonpharmacologic and pharmacologic therapies. The nurse uniquely designed the nursing care based on the infant's behavioral symptoms to minimize withdrawal symptoms.
Nurses who assess infants with jitteriness, myoclonic jerks, excessive moro reflexes, and neurologic hypersensitivity can use treatments that may help the newborn relax.
In many cases, even with continued thorough nursing assessments and individualized non-pharmacologic care of the NAS newborn, a pharmacologic intervention has to be initiated. Pharmacologic therapy is designed to be a short-term agent used to improve the clinical symptomology of NAS. The goal of the therapy is to mitigate the signs of withdrawal, seizures, fever, weight loss, and dehydration. Although guidelines suggest the preferred treatment method is opioid therapy, there is no universal standard of care, and variations in practice exist.
Each medication has advantages and disadvantages, and recent research suggests that a standardized protocol for the pharmacological treatment of NAS is more important than which drug is used to treat it. Improved standardization of nursing assessment, standards of nursing care, pharmacological treatment plans, and weaning protocols lead to shorter durations of medication use and reduced length of hospitalization. Discharge planning of the NAS infant must involve a multidisciplinary team. The mother's health and her maternal functioning, mental health, substance abuse treatment, the home environment, and support systems must all be assessed. Healthcare providers should educate the mother on sudden infant death syndrome (SIDS), sleeping positions, ongoing substance use disorder treatment, infant signs of infection, and the traditional newborn education received during the postpartum period.
The long-term effects of intrauterine opioid exposure on the child's development are difficult to determine because of the small sample sizes of published studies and other variables. Prenatal variables include polysubstance exposure, low birth weight, intrauterine growth restriction, etc., and postnatal variables range from continued maternal drug abuse, socioeconomic status, maternal educational levels, and other multiple factors.
Newborns with intrauterine exposure to opioids are at risk for developing NAS after birth. Recently, researchers noted that male infants are more likely to be diagnosed with NAS when compared to females. Researchers have also found that maternal polysubstances combined with benzodiazepines, cigarettes, and male-gender newborns have been associated with increased severity of NAS (Anbalagan et al., 2023).
Additionally, there is a greater risk for a newborn to develop NAS when they were exposed for greater than 30 days in utero compared to a shorter duration of exposure, and there was a greater risk when the opioid exposure was during the third versus first or second-trimester intrauterine exposure (Anbalagan et al., 2023).
Identifying infants at risk for NAS and standardized treatment of newborns with NAS are strategies to reduce NAS effects. Nonpharmacological treatment plans should be initiated first, including rooming in, breastfeeding, minimizing stimuli, swaddling, and others discussed in the above sections. Pharmacologic therapies should be coupled with customized nonpharmacologic strategies as recommended by the Academy of Pediatrics.
Baby boy Jack was born at 37 weeks gestation to a mother who received fragmented prenatal care. At 24 hours of age, the postpartum nurse notes that his respiratory rate is 65, and he has nasal congestion, increased moro reflex, mild tremors, and a high-pitched cry. The mother has been exclusively breastfeeding and reports that he cluster-fed most of the night.
Think about:
After talking with the women's health social worker, Jack's mom revealed she had a history of heroin use, and one year ago, she overdosed and started a methadone program. She could not commit to the program and began buying methadone off the street. She also admitted to intermittently smoking marijuana for many years.
Think about:
The Eat, Sleep, and Console approach was initiated to care for the newborn and mother. The social worker, provider, and nurse worked together to establish a plan with the mother to best care for her infant experiencing withdrawal.
CEUFast, Inc. is committed to furthering diversity, equity, and inclusion (DEI). While reflecting on this course content, CEUFast, Inc. would like you to consider your individual perspective and question your own biases. Remember, implicit bias is a form of bias that impacts our practice as healthcare professionals. Implicit bias occurs when we have automatic prejudices, judgments, and/or a general attitude towards a person or a group of people based on associated stereotypes we have formed over time. These automatic thoughts occur without our conscious knowledge and without our intentional desire to discriminate. The concern with implicit bias is that this can impact our actions and decisions with our workplace leadership, colleagues, and even our patients. While it is our universal goal to treat everyone equally, our implicit biases can influence our interactions, assessments, communication, prioritization, and decision-making concerning patients, which can ultimately adversely impact health outcomes. It is important to keep this in mind in order to intentionally work to self-identify our own risk areas where our implicit biases might influence our behaviors. Together, we can cease perpetuating stereotypes and remind each other to remain mindful to help avoid reacting according to biases that are contrary to our conscious beliefs and values.
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